Study links SWI/SNF disruption to changes in 3D genome structure
A Nature study reported that loss of canonical BAF, a SWI/SNF chromatin-remodeling complex, increased CTCF and cohesin activity and altered 3D genome organization.
Researchers reported that disrupting canonical BAF changed chromatin accessibility and reorganized genome domains in cell and mouse models.
The study describes a mechanism that may help explain effects of BAF-complex mutations, which occur across several cancer types.